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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SOS2
All Species:
37.88
Human Site:
Y293
Identified Species:
83.33
UniProt:
Q07890
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q07890
NP_008870.2
1332
152979
Y293
E
E
Q
A
F
D
P
Y
E
T
L
S
Q
D
I
Chimpanzee
Pan troglodytes
XP_515425
1598
179688
Y560
E
E
L
A
F
D
P
Y
E
S
Y
A
R
D
I
Rhesus Macaque
Macaca mulatta
XP_001099864
1331
152695
Y293
E
E
Q
A
F
D
P
Y
E
T
L
S
Q
D
I
Dog
Lupus familis
XP_547804
1363
156214
Y324
E
E
Q
A
F
D
P
Y
E
T
L
S
Q
D
I
Cat
Felis silvestris
Mouse
Mus musculus
Q02384
1333
153108
Y294
E
E
Q
A
F
D
P
Y
E
T
L
S
Q
D
I
Rat
Rattus norvegicus
NP_001129033
1333
153157
Y294
E
E
Q
A
F
D
P
Y
E
T
L
S
Q
D
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515100
1332
152934
Y293
E
E
Q
A
F
D
P
Y
E
T
L
S
Q
E
I
Chicken
Gallus gallus
XP_421461
1466
167231
Y429
E
E
Q
A
F
D
P
Y
E
T
L
S
Q
D
I
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_690171
1343
153249
Y290
E
E
Q
A
F
D
P
Y
E
T
L
S
Q
D
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P26675
1596
177916
K341
A
E
E
F
D
V
Y
K
K
Y
A
Y
D
V
T
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_782335
1310
150821
Y293
E
A
E
E
F
E
V
Y
S
P
Y
A
A
Q
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
58.7
99
93.2
N.A.
94.9
94.6
N.A.
91.1
78.9
N.A.
73
N.A.
39.8
N.A.
N.A.
52.1
Protein Similarity:
100
68.5
99.7
95.5
N.A.
97.9
97.4
N.A.
95.9
84.7
N.A.
83.9
N.A.
55.1
N.A.
N.A.
68
P-Site Identity:
100
66.6
100
100
N.A.
100
100
N.A.
93.3
100
N.A.
100
N.A.
6.6
N.A.
N.A.
26.6
P-Site Similarity:
100
86.6
100
100
N.A.
100
100
N.A.
100
100
N.A.
100
N.A.
20
N.A.
N.A.
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
10
0
82
0
0
0
0
0
0
10
19
10
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
10
82
0
0
0
0
0
0
10
73
0
% D
% Glu:
91
91
19
10
0
10
0
0
82
0
0
0
0
10
0
% E
% Phe:
0
0
0
10
91
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
91
% I
% Lys:
0
0
0
0
0
0
0
10
10
0
0
0
0
0
0
% K
% Leu:
0
0
10
0
0
0
0
0
0
0
73
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
82
0
0
10
0
0
0
0
0
% P
% Gln:
0
0
73
0
0
0
0
0
0
0
0
0
73
10
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% R
% Ser:
0
0
0
0
0
0
0
0
10
10
0
73
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
73
0
0
0
0
10
% T
% Val:
0
0
0
0
0
10
10
0
0
0
0
0
0
10
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
10
91
0
10
19
10
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _